دانلود گزارش کارورزی و کار آموزی

چکیده : 

tDiabetes mellitus is a group of complicated metabolic disorders characterized by high blood glucoselevel and inappropriate insulin secreting capacity due to decreased glucose metabolism and pancre-atic cell mass or dysfunction of cells. Thus, improving glucose metabolism and preserving cellmass and function might be useful for the treatment of diabetes. In this study, a novel acidic polysac-charide LBP-s-1 extracted from Lycium barbarum L. was obtained by purification using macroporousresin and ion-exchanged column. Monosaccharide composition analysis indicated that LBP-s-1 was com-prised of rhamnose, arabinose, xylose, mannose, glucose, galactose, galacturonic acid in the molar ratioof 1.00:8.34:1.25:1.26:1.91:7.05:15.28. The preliminary structure features of LBP-s-1 were investigatedby FT-IR,1H NMR and13C NMR. In vitro and in vivo hypoglycemic experiments showed that LBP-s-1 hadsignificant hypoglycemic effects and insulin-sensitizing activity through increasing glucose metabolismand insulin secretion and promoting pancreatic cell proliferation. Preliminary mechanisms were alsoelucidated.