دانلود گزارش کارورزی و کار آموزی

چکیده :

This paper formulates a class of models for the joint behaviour of a sequence of longitudinal

measurements and an associated sequence of event times, including single-event survival data. This class

includes and extends a number of specific models which have been proposed recently, and, in the absence

of association, reduces to separate models for the measurements and events based, respectively, on a

normal linear model with correlated errors and a semi-parametric proportional hazards or intensity model

with frailty.

Special cases of the model class are discussed in detail and an estimation procedure which allows the

two components to be linked through a latent stochastic process is described. Methods are illustrated using

results from a clinical trial into the treatment of schizophrenia.