دانلود گزارش کارورزی و کار آموزی

چکیده : 

This paper is a survey of existing estimation methods for pharmacokinetic/pharmacodynamic (PK/PD)

models based on stochastic differential equations (SDEs). Most parametric estimation methods proposed

for SDEs require high frequency data and are often poorly suited for PK/PD data which are usually sparse.

Moreover, PK/PD experiments generally include not a single individual but a group of subjects, leading to a

population estimation approach. This review concentrates on estimation methods which have been applied

to PK/PD data, for SDEs observed with and without measurement noise, with a standard or a population

approach. Besides, the adopted methodologies highly differ depending on the existence or not of an explicit

transition density of the SDE solution.