چکیده :
Background: Recent research suggests that Tourette’s syndrome (TS) may result from a defect
in the dopamine system. Several candidate gene polymorphisms have been implicated in
attention deficit hyperactivity disorder, including the dopamine transporter (DAT1) and
dopamine b-hydroxylase (DBH) genes. A high rate of comorbidity between attention deficit
hyperactivity disorder and TS indicates that they may share the same pathophysiology.
Purpose: We aimed to test the hypothesis that the dopamine gene might play a role in TS.
Methods: An association study, using an independent sample of patients from the midland
region of Taiwan, was performed to investigate whether DAT1 and DBH gene polymorphisms
can be used as markers of susceptibility to TS. A total of 160 children with TS and 83 normal
control participantswere includedin the study. Polymerase chainreactionwas usedto identify
polymorphisms in the DAT1 (40 bp VNTR) and DBH (TaqI A2) genes. Genotypes and allelic
frequencies for the DAT1 and DBH gene polymorphisms in both groups were compared.
Results: The results showed that genotypes and allelic frequencies in both groups were
not significantly different. The most common genotype for DAT1 (40 bp VNTR) was the
10,10 homozygote in both groups. The most common genotype for DBH (TaqI A2) was the
T homozygote in both groups.
Conclusion: These data suggest that the DAT1 and DBH genes may not be useful markers to
predict susceptibility to TS.
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